Lots of exciting papers below!
1. Cell Type-Specific Inhibitory Inputs to Dendritic and Somatic Compartments of Parvalbumin-Expressing Neocortical Interneuron Hiroyuki Hioki, Shinichiro Okamoto, Michiteru Konno, Hiroshi Kameda, Jaerin Sohn, Eriko Kuramoto, Fumino Fujiyama, and Takeshi Kaneko ; J Neuroscience 2013 (link)
The quest towards cell type specific circuits continues!
2. Neocortical Somatostatin-Expressing GABAergic Interneurons Disinhibit the Thalamorecipient Layer 4 Han Xu, Hyo-Young Jeong, Robin Tremblay, and Bernardo Rudy ; Neuron 2013 (link)
More cell type specificity!
3. Parallel Processing of Environmental Recognition and Locomotion in the Mouse Striatum Hagar G. Yamin, Edward A. Stern, and Dana Cohen ; J Neuro 2013 (link)
Parallel processing streams are exciting. The striatum occupies a bit of a blind spot in my neuro-knowledge so I wanted to add this to my list.
4. Cortico-cortical projections in mouse visual cortex are functionally target specific Lindsey L Glickfeld, Mark L Andermann, Vincent Bonin & R Clay Reid ; Nature Neuroscience 2013 (link)
This is an exciting paper that adds to the exceptional work from Clay Reid using calcium imaging to ask some important basic questions about cortical processing.
This paper asks if the projections to the higher visual areas from V1 are functionally specific or not. They frame the question as having two possibilities (excerpts from the paper and figure below):
1. “One possibility is that the net input from V1 to each target area reflects the diverse visual response tuning of all V1 neurons (Fig. 1a, top). In this model each higher visual area receives the same input, and its functional properties may be determined through local computations. “
2. “Alternatively, V1 may provide functionally distinct input to each downstream area (Fig. 1a, bottom). In this model, these target-specific projections could account for the specialization found in the higher visual areas.”
This paper is a good example of the increase in work being published on the mouse visual system There is a big movement headed up by Dr. Reid and Christof Koch at the Allen Brain Institute called Mindscope. It will be interesting to see how it works out. You can read about Mindscope in a Nature commentary here. Also Dr. Reid and Dr. Kock have been presenting a really great lecture series called, “Coding & Vision 101” you can check out here! I highly recommend it if you are interested in the visual system and interested in a good general overview.
Speaking of the mouse visual system, there was a great bundle of papers published last year on some functional mapping from the Reid and Callaway labs. It’s kind of funny that the two papers have almost identical titles 🙂
The editorial, Exploring the Next Frontier of Mouse Vision is here.
Reid lab: Functional Specialization of Mouse Higher Visual Cortical Areas (link)
Callaway lab: Functional Specialization of Seven Mouse Visual Cortical Areas (link)
Anyway, looking forward to reading this paper.
5. Neuronal correlates of visual time perception at brief timescales J. Patrick Mayo, and Marc A. Sommer ; PNAS 2013 (link)
6. Biased Associative Representations in Parietal Cortex Jamie K. Fitzgerald, David J. Freedman, Alessandra Fanini, Sharath Bennur, Joshua I. Gold, and John A. Assad ; Neuron 2013 (link)
John Assad presented a lot of this work and similar studies carried out by David Freedman at last years COSYNE meeting. I think it is really good work and very interesting.
7. Distinct Roles of Medial and Lateral Entorhinal Cortex in Spatial Cognition Tiffany Van Cauter, Jeremy Camon, Alice Alvernhe, Coralie Elduayen, Francesca Sargolini and Etienne Save ; Cerebral Cortex 2013 (link)
8. Functional Microcircuit Recruited during Retrieval of Object Association Memory in Monkey Perirhinal Cortex Toshiyuki Hirabayashi, Daigo Takeuchi, Keita Tamura, and Yasushi Miyashita ; Neuron 2013 (link)
9. Organization of Cortical and Thalamic Input to Pyramidal Neurons in Mouse Motor Cortex Bryan M. Hooks, Tianyi Mao, Diego A. Gutnisky, Naoki Yamawaki, Karel Svoboda, and Gordon M. G. Shepherd ; J Neuro 2013 (link)
Really detailed beautiful exploration of functional connectivity using the channelrhodopsin-2-assisted circuit mapping technique. If you aren’t familiar with this technique it is based on the beautiful caged glutamate mapping that Gordon Shepherd (Jr.) and Karel Svoboda refined, but in many ways even better 🙂 You can read about it from two early papers using the powerful technique here and here.
10. Deconstructing Complexity: Serial Block-Face Electron Microscopic Analysis of the Hippocampal Mossy Fiber Synapse Scott A. Wilke, Joseph K. Antonios, Eric A. Bushong, Ali Badkoobehi, Elmar Malek, Minju Hwang, Masako Terada, Mark H. Ellisman, and Anirvan Ghosh ; J Neuro 2013 (link)
I think this is just an amazing demonstration of some of the future of neuroscience!
11. Feedback Inhibition Enables Theta-Nested Gamma Oscillations and Grid Firing Fields Hugh Pastoll, Lukas Solanka, Mark C.W. van Rossum, and Matthew F. Nolan; Neuron 2013 (link)
This looks very interesting!
12. Brain Reactivity Differentiates Subjects with High and Low Dream Recall Frequencies during Both Sleep and Wakefulness Jean-Baptiste Eichenlaub, Olivier Bertrand, Dominique Morlet and Perrine Ruby ; Cerebral Cortex 2013 (link)
I just thought this sounded neat because dreaming is one of those neat things on the fringe of neuroscience research.
13. In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons Andres De la Rossa, Camilla Bellone, Bruno Golding, Ilaria Vitali, Jonathan Moss, Nicolas Toni, Christian Lüscher & Denis Jabaudon ; Nature Neuroscience 2013 (link)
This final paper just looks amazing! I mean WOW! Can we all just step back for a few seconds and look at what this paper actually does?!
The progress being made in genetics from induced pluripotent stem cells to stuff like this just blows my mind. It is an exciting time to be in neuroscience and biological sciences in general!